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News The safety

The safety

Let's reveal a little the topic of the safety of using various drugs for the treatment of oncology.

Indeed, during treatment, it is important not only to recover, but also not to harm the body with drugs. Any medicinal product in the instructions for use has a section "side effects", and before use, it is imperative to study this section.

For example, let's take AbbVie's Humira, which had sales of about $ 100 billion over 10 years.

Side effects:

In about 14% of patients, reactions at the injection site can be expected.

Infections: Very common - infections of the respiratory tract (including infections of the upper and lower respiratory tract, pneumonia, sinusitis, pharyngitis, nasopharyngitis, and herpes viral pneumonia); Often - generalized infections (including sepsis, candidiasis, and influenza), gastrointestinal infections (including viral gastroenteritis), skin and soft tissue infections (including paronychia, cellulitis, impetigo, necrotizing fasciitis and shingles), ear infections, oral infections (including simple herpes, oral herpes and dental lesions), genital infections (including vulvovaginal mycotic infection), urinary tract infections (including pyelonephritis), fungal infections, joint infections; Uncommon - opportunistic infections and tuberculosis (including coccidioidomycosis, histoplasmosis and a complex of infections caused by Mycobacterium avium), neurological infections (including viral meningitis), eye infections, bacterial infections.

Neoplasms: Often - benign neoplasms, skin cancer other than melanoma (including basal cell carcinoma and squamous cell carcinoma); Uncommon - lymphoma, parenchymal neoplasms (including breast cancer, lung and thyroid neoplasms), melanoma.

Blood and lymphatic system disorders: Very often - leukopenia (including neutropenia and agranulocytosis), anemia; Often - thrombocytopenia, leukocytosis; Uncommon - idiopathic thrombocytopenic purpura; Rarely, pancytopenia.

Immune system disorders: Often - hypersensitivity reactions, allergic reactions (including seasonal allergies).

From the side of metabolism: Very often - an increase in the concentration of lipids; Often - hypokalemia, increased uric acid concentration, abnormal sodium concentrations, hypocalcemia, hyperglycemia, hypophosphatemia, dehydration.

Mental Disorders: Often - mood changes (including depression), anxiety disorders, insomnia.

From the nervous system: Very often - headache; Often - paresthesia (including hypesthesia), migraine, sciatic nerve neuralgia, vestibular dizziness; Uncommon - tremor, neuropathy; Rarely - multiple sclerosis.

From the senses: Often - conjunctivitis, visual impairment, blepharitis, eyelid edema; Uncommon - diplopia, deafness, ringing in the ears.

From the side of the cardiovascular system: Often - increased blood pressure, hot flashes, hematomas, tachycardia; Uncommon - arrhythmia, chronic heart failure, arterial occlusion, thrombophlebitis, aortic aneurysm; Rarely cardiac arrest.

Respiratory system disorders: Often - cough, asthma, dyspnea; Infrequently - chronic obstructive pulmonary disease, interstitial lung disease, pneumonitis.

From the digestive system: Very often - nausea, vomiting, abdominal pain, increased activity of liver enzymes; Often - dyspepsia, gastroesophageal reflux, dry mouth, gastrointestinal bleeding; Uncommon - pancreatitis, dysphagia, facial edema, cholecystitis, cholelithiasis, increased bilirubin concentration, hepatic steatosis.

Skin and subcutaneous tissue disorders: Very often - rash (including exfoliative); Often - itching, urticaria, hemorrhages (including purpura), dermatitis (including eczema), brittle nails, hyperhidrosis; Infrequently - night sweats, scars.

From the musculoskeletal system: Very often - musculoskeletal pain; Often - muscle spasms; Infrequently - rhabdomyolysis, systemic lupus erythematosus.

From the genitourinary system: Often - hematuria, renal failure; Infrequently - nocturia, erectile dysfunction.

Others, including reactions at the injection site: Very often - reactions at the injection site (including

erythema); Often - chest pain, swelling, impaired wound healing; Infrequently - inflammation.

Laboratory indicators: Often - disorders in the blood coagulation system (including an increase in activated partial thromboplastin time), positive tests for autoantibodies (including antibodies to the double helix of DNA), an increase in the concentration of lactate dehydrogenase.

This is very impressive list of side effects of the drug, and a reasonable question arises: how much does the health of the body decrease after such a method of treatment? Any other similar drug has similar list of side effects, with minor changes ...

Why does the medicine have such side effects? The main reason is that treatment is not aimed at combating the cause of the disease, but at its consequences, and the way in which this is done is poisoning the body, where cancer cells must die ... And here the question is, what will be stronger: an organism or a disease?

Unlike these drugs

AstroMelanin is non-toxic and does not cause side effects on other organs and systems of the body.

Studies of cell biomass and AstroMelanin strains 365 and 1–365 isolated from them in accordance with GOST 28178–89 on a specific test object showed a complete absence of acute toxicity, which proves the safety of AstroMelanin.

Thus, the results obtained on the acute toxicity of AstroMelanin allow us to recommend its further study under the "mini-toxi" program (leading researcher of the laboratory of toxicology L.M. Mikhailova).

AstroMelanin opens a fundamentally new direction in the treatment of cancer patients. AstroMelanin is characterized by an intense anti-radical effect, stopping the avalanche of labial free radicals that affect healthy cells and tissues of the diseased body. This property is inherent in the very structure of AstroMelanin.

This makes it possible to use AstroMelanin for the correction of disorders underlying free radical pathologies, which, in particular, is the tumor process. Primarily for the treatment and prevention of relapses and metastases in cancer patients after radical treatment, the prevention of malignant neoplasms in borderline forms of disease, and the same goal in families with a high oncological risk.

United Financial Group is preparing for preclinical studies of AstroMelanin. Now there are laboratory studies, analysis, and preparation of a technological map for the production of the drug.

 


 

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